The geopolitics of the Strait of Hormuz is one of the main and continuous factors in the Iran-Oman relationship. Iran and Oman are respectively located on the north and south coasts of the Strait. This factor requires them to maintain good-neighborly relations regardless of what happens at the regional or international levels. Iran and Oman assume that there is a close connection between the security of the Strait of Hormuz and their own security. This point strengthens their motivation to maintain a close and friendly relationship. The two countries are aware of the fact that geographical factors are not subject to change. Their geographical proximity via the Strait of Hormuz, Oman’s relative remoteness from the Arab world and the geopolitical and geostrategic importance of the Strait have required Iran and Oman to maintain a good, neighborly relationship with one another. On that basis, and despite the fact that Oman has always had close relations with the United States and recently developed its ties with Israel, its friendly relationship with Iran has largely remained intact. This paper seeks to examine the role of the Strait of Hormuz in the relations between Iran and Oman from a historic, economic, strategic and security perspective.